Nkx2-2 anticorps (AA 1-119) (CF®568)

N° du produit ABIN6181418

Cet anticorps anti-Nkx2-2 est un anticorps Souris Monoclonal détectant Nkx2-2 dans IF, IHC et FACS. Adapté pour Humain.

Aperçu rapide pour Nkx2-2 anticorps (AA 1-119) (CF®568) (ABIN6181418)

Antigène: Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Nkx2-2 est conjugé à/à la CF®568

Application: Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: NX2-1523

Détail du produit anti-Nkx2-2 anticorps (CF®568)

Épitope: AA 1-119

Fonction: Mouse Monoclonal anti-NKX2.2 (NX2/1523), CF568 Conjugate

Attributs du produit: Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93 % and a specificity of 89 %, and aids in the differential diagnosis of small round cell tumors. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Human recombinant NKX2.2 protein fragment (aa1-119) (exact sequence is proprietary)

Isotype: IgG1 kappa

Information d'application

Indications d'application: Immunohistology (formalin) 1-2 μg/mL

• Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 min
• Flow Cytometry 0.5-1 μg/million cells/0.1 mL
• Immunofluorescence 1-2 μg/mL
• Optimal dilution for a specific application should be determined by user

Commentaires:

Pancreas or Ewing s sarcoma

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Détails sur Nkx2-2

Antigène: Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

Autre désignation: NKX2.2

Sujet: Homeobox protein NK-2 homolog B, NK2 transcription factor like protein B, NK2 transcription factor related locus 2, NKX22, Nkx2b, tinman

Poids moléculaire: 40-50 kDa

ID gène: 4821, 516922

UniProt: O95096

Pathways: Dopaminergic Neurogenesis