CD46 anticorps (CF®594)

N° du produit ABIN6187850

Cet anticorps anti-CD46 est un anticorps Souris Monoclonal détectant CD46 dans FACS et IF. Adapté pour Humain.

Aperçu rapide pour CD46 anticorps (CF®594) (ABIN6187850)

Antigène: CD46

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD46 est conjugé à/à la CF®594

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: 122-2

Détail du produit anti-CD46 anticorps (CF®594)

Fonction: Mouse Monoclonal anti-CD46 (122.2), CF594 Conjugate

Attributs du produit: CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4 into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant human CD46 protein

Isotype: IgG1 kappa

Information d'application

Indications d'application: Immunofluorescence 0.5-1 μg/mL

• Flow Cytometry 0.5-1 μg/million cells/0.1 mL
• Optimal dilution for a specific application should be determined by user

Commentaires:

HeLa, K-562 or MOLT-4 cells. Kidney

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Détails sur CD46

Antigène: CD46

Autre désignation: CD46

Sujet: AHUS2, CD46 antigen complement regulatory protein, Complement membrane cofactor protein, MCP, Measles virus receptor, Membrane cofactor protein, MIC10, TLX, Trophoblast leucocyte common antigen

Poids moléculaire: 56-66 kDa

ID gène: 4179, 510402

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization