Protein Phosphatase 4C anticorps

N° du produit ABIN6241238

Cet anticorps Souris Monoclonal détecte spécifiquement Protein Phosphatase 4C dans WB, ICC et IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Protein Phosphatase 4C anticorps (ABIN6241238)

Antigène: Protein Phosphatase 4C

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC)

Détail du produit

Immunogène: Recombinant Protein

Information d'application

Indications d'application: WB: 1:200. IHC: 1:100. ICC: 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: 4 °C,-20 °C

Détail du antigène

Antigène: Protein Phosphatase 4C

Sujet: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

UniProt: P60510