CHD5 anticorps (AA 64-98)

N° du produit ABIN6242241

L’anticorps Lapin Polyclonal anti-CHD5 a été validé pour WB. Il convient pour détecter CHD5 dans des échantillons de Humain.

Aperçu rapide pour CHD5 anticorps (AA 64-98) (ABIN6242241)

Antigène: CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHD5 est non-conjugé

Application: Western Blotting (WB)

Clone: RB54755

Détail du produit anti-CHD5 anticorps

Épitope: AA 64-98

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CHD5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 64-98 amino acids from human CHD5.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur CHD5

Antigène: CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))

Autre désignation: CHD5

Sujet: Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non- methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys- 27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.

Poids moléculaire: 223050

UniProt: Q8TDI0