E2F8 anticorps (AA 835-865)

N° du produit ABIN6242297

Détail du produit anti-E2F8 anticorps

Antigène: E2F8 (E2F Transcription Factor 8 (E2F8))

Épitope: AA 835-865

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp E2F8 est non-conjugé

Application: Western Blotting (WB)

Homologie: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This E2F8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 835-865 amino acids from human E2F8.

Clone: RB54144

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur E2F8

Antigène: E2F8 (E2F Transcription Factor 8 (E2F8))

Autre désignation: E2F8 (E2F8 Produits)

Synonymes: anticorps MGC130750, anticorps E2F8, anticorps E2F-8, anticorps RGD1308091, anticorps 4432406C08Rik, anticorps AA410048, anticorps E2F transcription factor 8, anticorps E2F transcription factor 8 L homeolog, anticorps E2F8, anticorps e2f8.L, anticorps e2f8, anticorps E2f8

Sujet: Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.

Poids moléculaire: 94166

UniProt: A0AVK6