PHF1 anticorps (N-Term)

N° du produit ABIN6242526

Détail du produit anti-PHF1 anticorps

Antigène: PHF1 (PHD Finger Protein 1 (PHF1))

Épitope: AA 164-197, N-Term

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PHF1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PHF1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 164-197 amino acids from the N-terminal region of human PHF1.

Clone: RB48341

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur PHF1

Antigène: PHF1 (PHD Finger Protein 1 (PHF1))

Autre désignation: PHF1 (PHF1 Produits)

Synonymes: anticorps pcl1, anticorps xpcl1, anticorps MTF2L2, anticorps PCL1, anticorps PHF2, anticorps TDRD19C, anticorps hPHF1, anticorps AW557215, anticorps D17Ertd455e, anticorps Tctex-3, anticorps Tctex3, anticorps mPcl1, anticorps PHD finger protein 1 L homeolog, anticorps PHD finger protein 1, anticorps phf1.L, anticorps PHF1, anticorps Phf1

Sujet: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.

Poids moléculaire: 62106

UniProt: O43189