RBM8A anticorps (AA 79-112)

N° du produit ABIN6242599

Cet anticorps anti-RBM8A est un anticorps Lapin Polyclonal détectant RBM8A dans WB. Adapté pour Souris.

Aperçu rapide pour RBM8A anticorps (AA 79-112) (ABIN6242599)

Antigène: RBM8A (RNA Binding Motif Protein 8A (RBM8A))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RBM8A est non-conjugé

Application: Western Blotting (WB)

Clone: RB49687

Détail du produit anti-RBM8A anticorps

Épitope: AA 79-112

Homologie: X, B, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This RBM8A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 79-112amino acids from the Central region of human RBM8A.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur RBM8A

Antigène: RBM8A (RNA Binding Motif Protein 8A (RBM8A))

Autre désignation: RBM8A

Sujet: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. The MAGOH-RBM8A heterodimer is a component of the nonsense mediated decay (NMD) pathway. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the function is different from the established EJC assembly.

Poids moléculaire: 19889

UniProt: Q9Y5S9