RNF2 anticorps (AA 198-232)

N° du produit ABIN6242608

Détail du produit anti-RNF2 anticorps

Antigène: RNF2 (Ring Finger Protein 2 (RNF2))

Épitope: AA 198-232

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF2 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Mouse Rnf2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 198-232 amino acids from the Central region of Mouse Rnf2.

Clone: RB52337

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000. WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur RNF2

Antigène: RNF2 (Ring Finger Protein 2 (RNF2))

Autre désignation: Rnf2 (RNF2 Produits)

Synonymes: anticorps BAP-1, anticorps BAP1, anticorps DING, anticorps HIPI3, anticorps RING1B, anticorps RING2, anticorps AI326319, anticorps AI450156, anticorps AU019207, anticorps Ring1B, anticorps dinG, anticorps fa19h05, anticorps ring1b, anticorps wu:fa19h05, anticorps wz4556, anticorps bap-1, anticorps bap1, anticorps ding, anticorps hipi3, anticorps ring2, anticorps ring finger protein 2, anticorps ring finger protein 2 L homeolog, anticorps RNF2, anticorps Rnf2, anticorps rnf2, anticorps rnf2.L

Sujet: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. Association to the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes.

Poids moléculaire: 37623

UniProt: Q9CQJ4