PI4KB anticorps (N-Term)

N° du produit ABIN6242814

L’anticorps Lapin Polyclonal anti-PI4KB a été validé pour WB et IHC (p). Il convient pour détecter PI4KB dans des échantillons de Humain. Il y a 1 publication disponible.

Aperçu rapide pour PI4KB anticorps (N-Term) (ABIN6242814)

Antigène: PI4KB (Phosphatidylinositol 4-Kinase, Catalytic, beta (PI4KB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PI4KB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1676

Détail du produit anti-PI4KB anticorps

Épitope: AA 20-51, N-Term

Homologie: B, M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This PI4KCB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-51 amino acids from the N-terminal region of human PI4KCB.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-PI4KB (ABIN6242814)

Spickler, Lippens, Laberge, Desmeules, Bellavance, Garneau, Guo, Hucke, Leyssen, Neyts, Vaillancourt, Décor, OMeara, Franti, Gauthier: "Phosphatidylinositol 4-kinase III beta is essential for replication of human rhinovirus and its inhibition causes a lethal phenotype in vivo." dans: Antimicrobial agents and chemotherapy, Vol. 57, Issue 7, pp. 3358-68, (2013) (PubMed).

Détails sur PI4KB

Antigène: PI4KB (Phosphatidylinositol 4-Kinase, Catalytic, beta (PI4KB))

Autre désignation: PI4KCB

Sujet: Phosphoinositides are pivotal precursors to important second messengers and as signaling and molecules. Phosphatidylinositol 4-kinases (PI4Ks) are are crucial regulators of the phosphoinsitide cascade. PI4KCB is a wortmannin-sensitive PI 4-kinase responsible for regulating the synthesis of agonist-sensitive pools of polyphosphoinositides. The cellular reservoir of PI4KCB is predominantly cytosolic, however the protein is is activated strongly by recruitment to the membrane to stimulate phosphatidylinositol 4,5-bisphosphate synthesis at the plasma membrane. PI4KCB contains an N-terminal lipid kinase unique domain, which is shared by members of both the PI3 kinase and PI4 kinase families, and a C-terminal catalytic domain, which defines this protein as a member of a much larger protein/lipid kinase family.

Poids moléculaire: 91379

NCBI Accession: NP_001185702, NP_001185703, NP_001185704, NP_002642

UniProt: Q9UBF8

Pathways: Inositol Metabolic Process