SLUG anticorps (AA 98-129)

N° du produit ABIN6242822

Cet anticorps Lapin Polyclonal détecte spécifiquement SLUG dans WB, IF et IHC (p). Il présente une réactivité envers Humain, Rat et Souris et a été mentionné dans 3+ publications.

Aperçu rapide pour SLUG anticorps (AA 98-129) (ABIN6242822)

Antigène: SLUG

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLUG est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB01398

Détail du produit anti-SLUG anticorps

Épitope: AA 98-129

Homologie: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SLUG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-129 amino acids from the Central region of human SLUG.

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:10~50. WB: 1:2000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-SLUG (ABIN6242822)

Carpenter, Paw, Dewhirst, Lo: "Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells." dans: Oncogene, Vol. 34, Issue 5, pp. 546-57, (2015) (PubMed).

Ferrari-Amorotti, Fragliasso, Esteki, Prudente, Soliera, Cattelani, Manzotti, Grisendi, Dominici, Pieraccioli, Raschellà, Chiodoni, Colombo, Calabretta: "Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion." dans: Cancer research, Vol. 73, Issue 1, pp. 235-45, (2013) (PubMed).

Lemma, Karihtala, Haapasaari, Jantunen, Soini, Bloigu, Pasanen, Turpeenniemi-Hujanen, Kuittinen: "Biological roles and prognostic values of the epithelial-mesenchymal transition-mediating transcription factors Twist, ZEB1 and Slug in diffuse large B-cell lymphoma." dans: Histopathology, Vol. 62, Issue 2, pp. 326-33, (2012) (PubMed).

Détails sur SLUG

Antigène: SLUG

Sujet: SLUG is a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporadic cases of neural tube defects.

Poids moléculaire: 29986

NCBI Accession: NP_003059

UniProt: O43623