SLUG anticorps (AA 98-129)

N° du produit ABIN6242822

Détail du produit anti-SLUG anticorps

Antigène: SLUG

Épitope: AA 98-129

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLUG est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Homologie: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SLUG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-129 amino acids from the Central region of human SLUG.

Clone: RB01398

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:10~50. WB: 1:2000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-SLUG (ABIN6242822)

Carpenter, Paw, Dewhirst, Lo: "Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells." dans: Oncogene, Vol. 34, Issue 5, pp. 546-57, (2015) (PubMed).

Ferrari-Amorotti, Fragliasso, Esteki, Prudente, Soliera, Cattelani, Manzotti, Grisendi, Dominici, Pieraccioli, Raschellà, Chiodoni, Colombo, Calabretta: "Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion." dans: Cancer research, Vol. 73, Issue 1, pp. 235-45, (2013) (PubMed).

Lemma, Karihtala, Haapasaari, Jantunen, Soini, Bloigu, Pasanen, Turpeenniemi-Hujanen, Kuittinen: "Biological roles and prognostic values of the epithelial-mesenchymal transition-mediating transcription factors Twist, ZEB1 and Slug in diffuse large B-cell lymphoma." dans: Histopathology, Vol. 62, Issue 2, pp. 326-33, (2012) (PubMed).

Détails sur SLUG

Antigène: SLUG

Abstract: SLUG Produits

Synonymes: anticorps Slug, anticorps Slugh, anticorps Snail2, anticorps SLUG, anticorps SLUGH, anticorps SLUGH1, anticorps SNAIL2, anticorps WS2D, anticorps snail family zinc finger 2, anticorps snail family transcriptional repressor 2, anticorps Snai2, anticorps SNAI2

Sujet: SLUG is a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporadic cases of neural tube defects.

Poids moléculaire: 29986

NCBI Accession: NP_003059

UniProt: O43623