DIAPH1 anticorps (N-Term)

N° du produit ABIN6242839

Cet anticorps anti-DIAPH1 est un anticorps Lapin Polyclonal détectant DIAPH1 dans WB. Adapté pour Humain.

Aperçu rapide pour DIAPH1 anticorps (N-Term) (ABIN6242839)

Antigène: DIAPH1 (Diaphanous Homolog 1 (DIAPH1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DIAPH1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB30760

Détail du produit anti-DIAPH1 anticorps

Épitope: AA 18-52, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This DIAPH1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 18-52 amino acids from the N-terminal region of human DIAPH1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur DIAPH1

Antigène: DIAPH1 (Diaphanous Homolog 1 (DIAPH1))

Autre désignation: DIAPH1

Sujet: Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Poids moléculaire: 141347

UniProt: O60610

Pathways: Sensory Perception of Sound