Nanog anticorps (AA 155-189)

N° du produit ABIN6242860

Cet anticorps anti-Nanog est un anticorps Lapin Polyclonal détectant Nanog dans WB. Adapté pour Humain.

Aperçu rapide pour Nanog anticorps (AA 155-189) (ABIN6242860)

Antigène: Nanog (NANOG) (Nanog Homeobox (NANOG))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nanog est non-conjugé

Application: Western Blotting (WB)

Clone: RB52819

Détail du produit anti-Nanog anticorps

Épitope: AA 155-189

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This NANOG antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 155-189 amino acids from the Central region of human NANOG.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000. WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur Nanog

Antigène: Nanog (NANOG) (Nanog Homeobox (NANOG))

Autre désignation: NANOG

Sujet: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'- [CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.

Poids moléculaire: 34620

UniProt: Q9H9S0

Pathways: Stem Cell Maintenance