BRCC3 anticorps (AA 18-50)

N° du produit ABIN6243065

Cet anticorps Lapin Polyclonal détecte spécifiquement BRCC3 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour BRCC3 anticorps (AA 18-50) (ABIN6243065)

Antigène: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRCC3 est non-conjugé

Application: Western Blotting (WB)

Clone: RB53911

Détail du produit anti-BRCC3 anticorps

Épitope: AA 18-50

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This BRCC3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 18-50 amino acids from human BRCC3.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur BRCC3

Antigène: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Autre désignation: BRCC3

Sujet: Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not have activity toward 'Lys- 48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'- specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.

Poids moléculaire: 36072

UniProt: P46736

Pathways: Positive Regulation of Response to DNA Damage Stimulus