PPIF anticorps (C-Term)

N° du produit ABIN6243145

Détail du produit anti-PPIF anticorps

Antigène: PPIF (Peptidylprolyl Isomerase F (PPIF))

Épitope: AA 183-217, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPIF est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PPIF antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 183-217 amino acids from the C-terminal region of human PPIF.

Clone: RB49693

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur PPIF

Antigène: PPIF (Peptidylprolyl Isomerase F (PPIF))

Autre désignation: PPIF (PPIF Produits)

Synonymes: anticorps CYP3, anticorps CyP-M, anticorps Cyp-D, anticorps CypD, anticorps CyP-D, anticorps ppif, anticorps wu:fd61c06, anticorps zgc:101753, anticorps AW457192, anticorps CyP-F, anticorps PPIase, anticorps Cyp-40, anticorps cypf, anticorps peptidylprolyl isomerase F, anticorps peptidylprolyl isomerase Fa, anticorps peptidylprolyl isomerase F (cyclophilin F), anticorps peptidylprolyl isomerase D, anticorps peptidylprolyl isomerase F L homeolog, anticorps PPIF, anticorps ppifa, anticorps Ppif, anticorps Ppid, anticorps ppif, anticorps ppif.L

Sujet: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis, the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress- induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.

Poids moléculaire: 22040

UniProt: P30405

Pathways: Proton Transport, Negative Regulation of intrinsic apoptotic Signaling, Negative Regulation of Transporter Activity