Dynamin 1-Like anticorps (C-Term)

N° du produit ABIN6243175

Cet anticorps anti-Dynamin 1-Like est un anticorps Lapin Polyclonal détectant Dynamin 1-Like dans WB. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour Dynamin 1-Like anticorps (C-Term) (ABIN6243175)

Antigène: Dynamin 1-Like (DNM1L)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Dynamin 1-Like est non-conjugé

Application: Western Blotting (WB)

Clone: RB52425

Détail du produit anti-Dynamin 1-Like anticorps

Épitope: AA 513-547, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This DNM1L antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 513-547 amino acids from the C-terminal region of human DNM1L.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:8000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur Dynamin 1-Like

Antigène: Dynamin 1-Like (DNM1L)

Autre désignation: DNM1L

Sujet: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis, this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles, the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution.

Poids moléculaire: 81877

UniProt: O00429