ULK3 anticorps (C-Term)

N° du produit ABIN6243328

Détail du produit anti-ULK3 anticorps

Antigène: ULK3 (Unc-51-Like Kinase 3 (ULK3))

Épitope: AA 435-468, C-Term

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ULK3 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This ULK3 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 435-468 amino acids from the C-terminal region of human ULK3.

Clone: 1404CT148-89-25

Isotype: IgG1 kappa

Information d'application

Indications d'application: IHC: 1:50. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur ULK3

Antigène: ULK3 (Unc-51-Like Kinase 3 (ULK3))

Autre désignation: ULK3 (ULK3 Produits)

Synonymes: anticorps zgc:162196, anticorps 1200015E14Rik, anticorps unc-51 like kinase 3, anticorps unc-51 like kinase 3 L homeolog, anticorps unc-51-like kinase 3, anticorps ULK3, anticorps ulk3, anticorps Ulk3, anticorps ulk3.L

Sujet: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.

Poids moléculaire: 53444

UniProt: Q6PHR2