FER anticorps (AA 1-300)

N° du produit ABIN6243360

L’anticorps Souris Monoclonal anti-FER a été validé pour WB et IHC (p). Il convient pour détecter FER dans des échantillons de Humain et Souris. Il y a 1 publication disponible.

Aperçu rapide pour FER anticorps (AA 1-300) (ABIN6243360)

Antigène: FER (FER Tyrosine Kinase (FER))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FER est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1457CT181-12-17

Détail du produit anti-FER anticorps

Épitope: AA 1-300

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This FER antibody is generated from a mouse immunized with a recombinant protein.

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 1:2000. IHC-P: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-FER (ABIN6243360)

Meng, Chen, Zhang: "Intracellular Insulin and Impaired Autophagy in a Zebrafish model and a Cell Model of Type 2 diabetes." dans: International journal of biological sciences, Vol. 13, Issue 8, pp. 985-995, (2018) (PubMed).

Détails sur FER

Antigène: FER (FER Tyrosine Kinase (FER))

Autre désignation: FER

Sujet: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.

Poids moléculaire: 94638

UniProt: P16591