RNF126 anticorps (AA 84-115)

N° du produit ABIN6243426

L’anticorps anti-RNF126 Polyclonal Lapin est utilisé pour la détection de RNF126 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour RNF126 anticorps (AA 84-115) (ABIN6243426)

Antigène: RNF126 (Ring Finger Protein 126 (RNF126))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF126 est non-conjugé

Application: Western Blotting (WB)

Clone: RB54136

Détail du produit anti-RNF126 anticorps

Épitope: AA 84-115

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This RNF126 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 84-115 amino acids from the Central region of human RNF126.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur RNF126

Antigène: RNF126 (Ring Finger Protein 126 (RNF126))

Autre désignation: RNF126

Sujet: E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:< a href="http://www.uniprot.org/citations/24981174" target="_blank">24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:< a href="http://www.uniprot.org/citations/24275455" target="_blank">24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:< a href="http://www.uniprot.org/citations/23026136" target="_blank">23026136). May monoubiquitinate AICDA (PubMed:< a href="http://www.uniprot.org/citations/23277564" target="_blank">23277564).

Poids moléculaire: 33861

UniProt: Q9BV68