LARGE anticorps (AA 365-398)

N° du produit ABIN6243442

Cet anticorps anti-LARGE est un anticorps Lapin Polyclonal détectant LARGE dans WB. Adapté pour Humain.

Aperçu rapide pour LARGE anticorps (AA 365-398) (ABIN6243442)

Antigène: LARGE (Like-Glycosyltransferase (LARGE))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LARGE est non-conjugé

Application: Western Blotting (WB)

Clone: RB55257

Détail du produit anti-LARGE anticorps

Épitope: AA 365-398

Homologie: C, Zf, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This LARGE antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 365-398 amino acids from the Central region of human LARGE.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur LARGE

Antigène: LARGE (Like-Glycosyltransferase (LARGE))

Autre désignation: LARGE

Sujet: Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine- beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:< a href="http://www.uniprot.org/citations/22223806" target="_blank">22223806). Phosphorylated O- mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:< a href="http://www.uniprot.org/citations/25279699" target="_blank">25279699).

Poids moléculaire: 88066

UniProt: O95461