CHMP3 anticorps (N-Term)

N° du produit ABIN6243582

L’anticorps anti-CHMP3 Polyclonal Lapin est utilisé pour la détection de CHMP3 dans des échantillons de Humain et Souris. Il a été validé pour WB.

Aperçu rapide pour CHMP3 anticorps (N-Term) (ABIN6243582)

Antigène: CHMP3 (Charged Multivesicular Body Protein 3 (CHMP3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHMP3 est non-conjugé

Application: Western Blotting (WB)

Clone: RB51722

Détail du produit anti-CHMP3 anticorps

Épitope: AA 28-61, N-Term

Homologie: B, Pr, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CHMP3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 28-61 amino acids from the N-terminal region of human CHMP3.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur CHMP3

Antigène: CHMP3 (Charged Multivesicular Body Protein 3 (CHMP3))

Autre désignation: CHMP3

Sujet: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress- mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.

Poids moléculaire: 25073

UniProt: Q9Y3E7