COMMD1 anticorps

N° du produit ABIN6243631

Cet anticorps anti-COMMD1 est un anticorps Lapin Polyclonal détectant COMMD1 dans WB. Adapté pour Humain.

Aperçu rapide pour COMMD1 anticorps (ABIN6243631)

Antigène: COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COMMD1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB54338

Détail du produit anti-COMMD1 anticorps

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This COMMD1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 4--33 amino acids from human COMMD1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur COMMD1

Antigène: COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))

Autre désignation: COMMD1

Sujet: Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1, in vitro promotes CRL E3 activiy and dissocoiates CAND1 from CUL1 and CUL2 (PubMed:< a href="http://www.uniprot.org/citations/21778237" target="_blank">21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:< a href="http://www.uniprot.org/citations/15799966" target="_blank">15799966, PubMed:< a href="http://www.uniprot.org/citations/17183367" target="_blank">17183367, PubMed:< a href="http://www.uniprot.org/citations/20048074" target="_blank">20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:< a href="http://www.uniprot.org/citations/23515529" target="_blank">23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:< a href="http://www.uniprot.org/citations/14645214" target="_blank">14645214, PubMed:< a href="http://www.uniprot.org/citations/20237237" target="_blank">20237237, PubMed:< a href="http://www.uniprot.org/citations/21741370" target="_blank">21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:< a href="http://www.uniprot.org/citations/21483833" target="_blank">21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:< a href="http://www.uniprot.org/citations/20595380" target="_blank">20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans- Golgi network and vesicles in the cell periphery, the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:< a href="http://www.uniprot.org/citations/25355947" target="_blank">25355947). Can bind one copper ion per monomer (PubMed:< a href="http://www.uniprot.org/citations/17309234" target="_blank">17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2) (PubMed:< a href="http://www.uniprot.org/citations/18940794" target="_blank">18940794). Involved in the regulation of HIF1A-mediated transcription, competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:< a href="http://www.uniprot.org/citations/20458141" target="_blank">20458141).

Poids moléculaire: 21178

UniProt: Q8N668

Pathways: Transition Metal Ion Homeostasis