MAD2L2 anticorps (C-Term)

N° du produit ABIN6243877

Cet anticorps anti-MAD2L2 Polyclonal Lapin (Clone RB48484) (ABIN6243877) détecte spécifiquement MAD2L2 dans WB, IF et IHC (p). L’anticorps est réactif avec des échantillons de Souris.

Aperçu rapide pour MAD2L2 anticorps (C-Term) (ABIN6243877)

Antigène: MAD2L2 (MAD2 Mitotic Arrest Deficient-Like 2 (MAD2L2))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAD2L2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB48484

Détail du produit anti-MAD2L2 anticorps

Épitope: AA 198-231, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This MAD2L2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 198-231 amino acids from the C-terminal region of human MAD2L2.

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:25. WB: 1:1000. IHC-P: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur MAD2L2

Antigène: MAD2L2 (MAD2 Mitotic Arrest Deficient-Like 2 (MAD2L2))

Autre désignation: MAD2L2

Sujet: Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.

Poids moléculaire: 24334

UniProt: Q9UI95