SNW1 anticorps (AA 464-497)

N° du produit ABIN6243922

Cet anticorps anti-SNW1 est un anticorps Lapin Polyclonal détectant SNW1 dans WB et IF. Adapté pour Humain et Souris.

Aperçu rapide pour SNW1 anticorps (AA 464-497) (ABIN6243922)

Antigène: SNW1 (SNW Domain Containing 1 (SNW1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNW1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: RB54232

Détail du produit anti-SNW1 anticorps

Épitope: AA 464-497

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SNW1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 464-497 amino acids from human SNW1.

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:25. WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur SNW1

Antigène: SNW1 (SNW Domain Containing 1 (SNW1))

Autre désignation: SNW1

Sujet: Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA, the function probbaly involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.

Poids moléculaire: 61494

UniProt: Q13573

Pathways: Retinoic Acid Receptor Signaling Pathway