PLK4 anticorps (AA 724-758)

N° du produit ABIN6243950

Cet anticorps Lapin Polyclonal détecte spécifiquement PLK4 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour PLK4 anticorps (AA 724-758) (ABIN6243950)

Antigène: PLK4 (Polo-Like Kinase 4 (PLK4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLK4 est non-conjugé

Application: Western Blotting (WB)

Clone: RB53118

Détail du produit anti-PLK4 anticorps

Épitope: AA 724-758

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PLK4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 724-758 amino acids from the region of human PLK4.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur PLK4

Antigène: PLK4 (Polo-Like Kinase 4 (PLK4))

Autre désignation: PLK4

Classe de substances: Phage Protein

Sujet: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2.

Poids moléculaire: 108972

UniProt: O00444

Pathways: M Phase