USP2 anticorps (AA 1-258)

N° du produit ABIN6244029

Détail du produit anti-USP2 anticorps

Antigène: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Épitope: AA 1-258

Reactivité: Humain, Green Monkey

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp USP2 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This USP2 antibody is generated from a mouse immunized with a recombinant protein between 1-258 amino acids from human USP2.

Clone: 1738CT331-50-87

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur USP2

Antigène: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Autre désignation: USP2 (USP2 Produits)

Synonymes: anticorps UBP41, anticorps USP9, anticorps B930035K21Rik, anticorps Ubp41, anticorps UBP-t, anticorps UBP46, anticorps ubp52, anticorps ubp66, anticorps zgc:92134, anticorps ubiquitin specific peptidase 2, anticorps ubiquitin specific peptidase 2a, anticorps USP2, anticorps Usp2, anticorps usp2a

Sujet: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).

Poids moléculaire: 68072

UniProt: O75604