RBMX anticorps (AA 262-294)

N° du produit ABIN6244063

Cet anticorps anti-RBMX est un anticorps Lapin Polyclonal détectant RBMX dans WB et IHC (p). Adapté pour Humain.

Aperçu rapide pour RBMX anticorps (AA 262-294) (ABIN6244063)

Antigène: RBMX (RNA Binding Motif Protein, X-Linked (RBMX))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RBMX est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB53803

Détail du produit anti-RBMX anticorps

Épitope: AA 262-294

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This RBMX antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 262-294 amino acids from the Central region of human RBMX.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000-1:2000. IHC-P: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur RBMX

Antigène: RBMX (RNA Binding Motif Protein, X-Linked (RBMX))

Autre désignation: RBMX

Sujet: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter, may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion, acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single- stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation, probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways, promotes both the IL-1- beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.

Poids moléculaire: 42332

UniProt: P38159

Pathways: Chromatin Binding, Ribonucleoprotein Complex Subunit Organization