SRGAP2 anticorps (C-Term)

N° du produit ABIN6244085

Cet anticorps Lapin Polyclonal détecte spécifiquement SRGAP2 dans WB. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour SRGAP2 anticorps (C-Term) (ABIN6244085)

Antigène: SRGAP2 (SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SRGAP2 est non-conjugé

Application: Western Blotting (WB)

Clone: RB53245

Détail du produit anti-SRGAP2 anticorps

Épitope: AA 1040-1071, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SRGAP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1040-1071amino acids from the C-terminal region of human SRGAP2.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur SRGAP2

Antigène: SRGAP2 (SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2))

Autre désignation: SRGAP2

Sujet: RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.

Poids moléculaire: 120871

UniProt: O75044