NDEL1 anticorps (AA 178-213)

N° du produit ABIN6244172

Cet anticorps Lapin Polyclonal détecte spécifiquement NDEL1 dans WB. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour NDEL1 anticorps (AA 178-213) (ABIN6244172)

Antigène: NDEL1 (NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 1 (NDEL1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NDEL1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB50842

Détail du produit anti-NDEL1 anticorps

Épitope: AA 178-213

Homologie: C, Pr, Rb, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This NDEL1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 178-213 amino acids from the Central region of human NDEL1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur NDEL1

Antigène: NDEL1 (NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 1 (NDEL1))

Autre désignation: NDEL1

Sujet: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.

Poids moléculaire: 38375

UniProt: Q9GZM8

Pathways: Regulation of Cell Size