MUL1 anticorps (AA 176-210)

N° du produit ABIN6244174

Détail du produit anti-MUL1 anticorps

Antigène: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))

Épitope: AA 176-210

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MUL1 est non-conjugé

Application: Western Blotting (WB)

Homologie: Pr, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This MUL1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 176-210 amino acids from the Central region of human MUL1.

Clone: RB49942

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur MUL1

Antigène: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))

Autre désignation: MUL1 (MUL1 Produits)

Synonymes: anticorps C1orf166, anticorps GIDE, anticorps MAPL, anticorps MULAN, anticorps RNF218, anticorps RP11-401M16.2, anticorps mul1, anticorps zgc:92166, anticorps 0610009K11Rik, anticorps AV000801, anticorps Gide, anticorps RGD1309944, anticorps im:7146383, anticorps zgc:165594, anticorps mitochondrial E3 ubiquitin protein ligase 1, anticorps mitochondrial E3 ubiquitin protein ligase 1 L homeolog, anticorps mitochondrial E3 ubiquitin protein ligase 1a, anticorps mitochondrial ubiquitin ligase activator of NFKB 1, anticorps mitochondrial E3 ubiquitin protein ligase 1b, anticorps MUL1, anticorps mul1.L, anticorps mul1a, anticorps Mul1, anticorps mul1b

Sujet: Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its abilty to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.

Poids moléculaire: 39800

UniProt: Q969V5

Pathways: Positive Regulation of Endopeptidase Activity