Endoglin anticorps (AA 74-251)

N° du produit ABIN6252250

L’anticorps anti-Endoglin Monoclonal Souris est utilisé pour la détection de Endoglin dans des échantillons de Humain. Il a été validé pour WB, FACS et IF.

Aperçu rapide pour Endoglin anticorps (AA 74-251) (ABIN6252250)

Antigène: Endoglin (ENG)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Endoglin est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: ENG-1326

Détail du produit anti-Endoglin anticorps

Épitope: AA 74-251

Purification: Protein G affinity chromatography

Immunogène: A partial recombinant protein corresponding to amino acids 74-251 of human CD105/Endoglin was used as the immunogen for the CD105 antibody.

Isotype: IgG1

Information d'application

Indications d'application: Immunofluorescence: 1-2 μg/mL

WB: 1-2 μg/mL

Flow Cytometry: 0.5-1 μg/million cells in 0.1ml

Titering of the CD105 antibody may be required for optimal performance.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot and Store at -20C. Avoid freez-thaw cycles.

Détails sur Endoglin

Antigène: Endoglin (ENG)

Autre désignation: CD105

Sujet: CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. CD105 has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. It is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.