PD-1 anticorps
-
- Antigène Voir toutes PD-1 (PDCD1) Anticorps
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
-
Reactivité
- Souris
-
Hôte
- Rat
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp PD-1 est non-conjugé
-
Application
- Flow Cytometry (FACS), Functional Studies (Func)
- Fonction
- anti-PD-1 (mouse), mAb (blocking) (1H10) (preservative free)
- Attributs du produit
- Monoclonal Antibody. Recognizes mouse PD-1 (CD279). Does not cross-react with human PD-1d. Isotype: Rat IgG2akappa. Clone: 1H10. Applications: FACS, FUNC (Blocking). Liquid. In PBS. CD279 (Programmed Cell Death Protein 1, PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
- Pureté
- >95 % (SDS-PAGE)
- niveau d'endotoxine
- <0.01EU/μg purified protein (LAL test, Lonza).
- Immunogène
- Mouse PD-1 transfected cell line.
- Clone
- 1H10
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product PDCD1 Anticorps primaire
-
-
- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. In PBS.
- Agent conservateur
- Without preservative
- Conseil sur la manipulation
- After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
-
Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
-
- Antigène
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
- Autre désignation
- PD-1 (PDCD1 Produits)
- Synonymes
- anticorps CD279, anticorps PD-1, anticorps PD1, anticorps SLEB2, anticorps hPD-1, anticorps hPD-l, anticorps Ly101, anticorps Pdc1, anticorps programmed cell death 1, anticorps PDCD1, anticorps Pdcd1
- Sujet
-
Alternate Names/Synonyms: CD279, Programmed Cell Death Protein 1
Product Description: CD279 (Programmed Cell Death Protein 1, PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
- NCBI Accession
- NP_005009
- Pathways
- Cancer Immune Checkpoints
-