FMR1 anticorps (pSer499)

N° du produit ABIN6254033

Cet anticorps Lapin Polyclonal détecte spécifiquement FMR1 dans WB, IHC et ELISA. Il présente une réactivité envers Rat et a été mentionné dans 4+ publications.

Aperçu rapide pour FMR1 anticorps (pSer499) (ABIN6254033)

Antigène: FMR1 (Fragile X Mental Retardation 1 (FMR1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FMR1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-FMR1 anticorps

Épitope: pSer499

Specificité: Specific for endogenous levels of the ~71 kDa FMRP protein phosphorylated at Ser499. Immunolabeling is completely eliminated by treatment with λ-phosphatase.

Réactivité croisée: Poulet, Humain, Souris, Rat

Homologie: bovine, canine, chicken, human, mouse, non-human primates, sheep, Xenopus, zebra fish

Attributs du produit: Our FMRP (Ser499) rabbit polyclonal phosphospecific primary antibody is produced in-house. It detects FMRP (Ser499) and is antigen affinity purified from pooled serum. It is great for use in ELISA, WB, IHC.

Purification: Prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho and non-phosphopeptide affinity columns.

Immunogène: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser499 of rat FMRP, conjugated to keyhole limpet hemocyanin (KLH).

Isotype: IgG

Information d'application

Indications d'application:

Dilution Range: WB Brain: 1:1000

Dilution Range: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Stockage commentaire: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Date de péremption: 12 months

Références pour anticorps anti-FMR1 (ABIN6254033)

Bartley, OKeefe, Blice-Baum, Mihailescu, Gong, Miyares, Karaca, Bordey: "Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP." dans: eNeuro, Vol. 3, Issue 6, (2017) (PubMed).

Reynolds, Smith, Jefferson, Lugo: "Comparison of Equivalence between Two Commercially Available S499-Phosphorylated FMRP Antibodies in Mice." dans: PLoS ONE, Vol. 10, Issue 11, pp. e0143134, (2016) (PubMed).

Guimarães-Souza, Perche, Morgans, Duvoisin, Calaza: "Fragile X Mental Retardation Protein expression in the retina is regulated by light." dans: Experimental eye research, Vol. 146, pp. 72-82, (2016) (PubMed).

Bartley, OKeefe, Bordey: "FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity." dans: PLoS ONE, Vol. 9, Issue 5, pp. e96956, (2015) (PubMed).

Détails sur FMR1

Antigène: FMR1 (Fragile X Mental Retardation 1 (FMR1))

Autre désignation: FMR1

Sujet:

Synonyms: FMR 1 antibody, Fmr1 antibody, Fmr1 gene antibody, FMR1_HUMAN antibody, FMRP antibody, Fragile X mental retardation 1 antibody, Fragile X mental retardation 1 protein antibody, Fragile X mental retardation protein 1 antibody, Fragile X mental retardation protein antibody, fragile X mental retardation syndrome-related protein 1 antibody, fragile X mental retardation autosomal homolog 1 antibody, FRAXA antibody, fxr1 antibody, MGC87458 antibody, POF antibody, POF1 antibody, Protein FMR-1 antibody, Protein FMR1 antibody, wu:fb16f11 antibody, wu:fd18c10 antibody, zgc:66226 antibody

Description Logic: Our FMRP (Ser499) rabbit polyclonal phosphospecific primary antibody is produced . It detects FMRP (Ser499) and is antigen affinity purified from pooled serum. It is great for use in ELISA, WB, IHC.

Gene Name Alternatives: FMR1

Poids moléculaire: 71 kDa

ID gène: 24948

UniProt: Q80WE1

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development