ATR anticorps (pSer428)

N° du produit ABIN6255330

L’anticorps anti-ATR Polyclonal Lapin est utilisé pour la détection de ATR dans des échantillons de Humain, Souris et Rat. Il a été validé pour IHC et WB.

Aperçu rapide pour ATR anticorps (pSer428) (ABIN6255330)

Antigène: ATR (ATR serine/threonine kinase (ATR))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATR est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Détail du produit anti-ATR anticorps

Épitope: pSer428

Fonction: Phospho-ATR (Ser428) Antibody

Specificité: Phospho -ATR(S428) Antibody detects endogenous levels of ATR only when phosphorylated at S428

Homologie: Pig,Horse,Rabbit,Dog

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human ATR around the phosphorylation site of Ser428.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ATR

Antigène: ATR (ATR serine/threonine kinase (ATR))

Autre désignation: ATR

Sujet:

Description: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

Gene: ATR

Poids moléculaire: 300 kDa

ID gène: 545

UniProt: Q13535

Pathways: Positive Regulation of Response to DNA Damage Stimulus