HDAC5 anticorps (pSer498)

N° du produit ABIN6255378

L’anticorps Lapin Polyclonal anti-HDAC5 a été validé pour WB, IHC, ELISA, IF et ICC. Il convient pour détecter HDAC5 dans des échantillons de Humain, Souris et Rat. Il y a 1 publication disponible.

Aperçu rapide pour HDAC5 anticorps (pSer498) (ABIN6255378)

Antigène: HDAC5 (Histone Deacetylase 5 (HDAC5))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HDAC5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-HDAC5 anticorps

Épitope: pSer498

Specificité: Phospho-HDAC5 (Ser498) Antibody detects endogenous levels of HDAC5 only when phosphorylated at Serine 498.

Homologie: Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human HDAC5 around the phosphorylation site of Ser498.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Références pour anticorps anti-HDAC5 (ABIN6255378)

Sarode, Neier, Shibata, Shen, Goncharov, Goncharova, Mazi, Joshi, Settles, LaSalle, Medici: "Wilson Disease: Intersecting DNA Methylation and Histone Acetylation Regulation of Gene Expression in a Mouse Model of Hepatic Copper Accumulation." dans: Cellular and molecular gastroenterology and hepatology, Vol. 12, Issue 4, pp. 1457-1477, (2022) (PubMed).

Détails sur HDAC5

Antigène: HDAC5 (Histone Deacetylase 5 (HDAC5))

Autre désignation: HDAC5

Sujet:

Description: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Gene: HDAC5

Poids moléculaire: 124kDa

ID gène: 10014

UniProt: Q9UQL6

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Monocarboxylic Acid Catabolic Process