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HNRNPC anticorps (pSer260)

HNRNPC Reactivité: Humain, Rat, Souris WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6256225
  • Antigène Voir toutes HNRNPC Anticorps
    HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))
    Épitope
    • 16
    • 15
    • 12
    • 8
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer260
    Reactivité
    • 72
    • 47
    • 33
    • 8
    • 8
    • 6
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 84
    • 3
    Lapin
    Clonalité
    • 73
    • 14
    Polyclonal
    Conjugué
    • 42
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HNRNPC est non-conjugé
    Application
    • 51
    • 30
    • 30
    • 19
    • 16
    • 14
    • 13
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    Phospho-hnRNP C1/C2 (Ser260) Antibody detects endogenous levels of hnRNP C1/C2 only when phosphorylated at Serine 260.
    Homologie
    Horse,Rabbit,Dog,Xenopus
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogène
    A synthesized peptide derived from human hnRNP C1/C2 around the phosphorylation site of Ser260.
    Isotype
    IgG
    Top Product
    Discover our top product HNRNPC Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))
    Autre désignation
    HNRNPC (HNRNPC Produits)
    Synonymes
    anticorps C1, anticorps C2, anticorps HNRNP, anticorps HNRPC, anticorps SNRPC, anticorps MGC53243, anticorps HNRNPC, anticorps bZ1G18.4, anticorps fb57h12, anticorps fi16b11, anticorps wu:fb57h12, anticorps wu:fi16b11, anticorps zgc:55701, anticorps AL022939, anticorps D14Wsu171e, anticorps Hnrpc, anticorps Hnrpc1, anticorps Hnrpc2, anticorps hnRNPC1, anticorps hnRNPC2, anticorps hnrnp-C, anticorps hnRNP C, anticorps hnrnp, anticorps hnrpc, anticorps snrpc, anticorps heterogeneous nuclear ribonucleoprotein C (C1/C2), anticorps heterogeneous nuclear ribonucleoprotein C (C1/C2) S homeolog, anticorps heterogeneous nuclear ribonucleoprotein C, anticorps heterogeneous nuclear ribonucleoprotein C (C1/C2) L homeolog, anticorps HNRNPC, anticorps hnrnpc.S, anticorps hnrnpc, anticorps Hnrnpc, anticorps hnrnpc.L
    Sujet

    Description: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm6A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).

    Gene: HNRNPC

    Poids moléculaire
    41kDa
    ID gène
    3183
    UniProt
    P07910
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