tau anticorps (pSer262, pSer579)

N° du produit ABIN6256228

Cet anticorps anti-tau Polyclonal Lapin (ABIN6256228) détecte spécifiquement tau dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour tau anticorps (pSer262, pSer579) (ABIN6256228)

Antigène: tau (tau Protein)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp tau est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-tau anticorps

Épitope: pSer262, pSer579

Fonction: Phospho-Tau (Ser262)[Ser579] Antibody

Specificité: Phospho-Tau (Ser262) Antibody detects endogenous levels of Tau only when phosphorylated at Ser579, which site historically referenced as Ser262.

Homologie: Pig,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human Tau around the phosphorylation site of Ser262.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur tau

Antigène: tau (tau Protein)

Autre désignation: Tau

Sujet:

Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Gene: MAPT

Poids moléculaire: 78 kDa

ID gène: 4137

UniProt: P10636