IQGAP1 anticorps (N-Term)

N° du produit ABIN6256871

Détail du produit anti-IQGAP1 anticorps

Antigène: IQGAP1 (IQ Motif Containing GTPase Activating Protein 1 (IQGAP1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IQGAP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: IQGAP1 Antibody detects endogenous levels of total IQGAP1.

Homologie: Pig,Bovine,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human IQGAP1, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur IQGAP1

Antigène: IQGAP1 (IQ Motif Containing GTPase Activating Protein 1 (IQGAP1))

Autre désignation: IQGAP1 (IQGAP1 Produits)

Synonymes: anticorps HUMORFA01, anticorps SAR1, anticorps p195, anticorps AA682088, anticorps D7Ertd237e, anticorps D7Ertd257e, anticorps mKIAA0051, anticorps IQ motif containing GTPase activating protein 1, anticorps IQGAP1, anticorps Iqgap1

Sujet:

Description: Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816).

Gene: IQGAP1

Poids moléculaire: 190 kDa

ID gène: 8826

UniProt: P46940

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2