Cyclin T2 anticorps (Internal Region)

N° du produit ABIN6257122

Détail du produit anti-Cyclin T2 anticorps

Antigène: Cyclin T2 (CCNT2)

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin T2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: CCNT2 Antibody detects endogenous levels of total CCNT2.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CCNT2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Date de péremption: 12 months

Détails sur Cyclin T2

Antigène: Cyclin T2 (CCNT2)

Autre désignation: CCNT2 (CCNT2 Produits)

Synonymes: anticorps fb16c03, anticorps wu:fb16c03, anticorps wu:fj68b10, anticorps zgc:55690, anticorps ccnt2, anticorps cycT, anticorps wu:fi17h07, anticorps zgc:55357, anticorps MGC81210, anticorps CCNT2, anticorps CYCT2, anticorps 2900041I18Rik, anticorps C81304, anticorps CycT2, anticorps CycT2b, anticorps cyclin T2, anticorps cyclin T2b, anticorps cyclin T2a, anticorps cyclin T2 S homeolog, anticorps CCNT2, anticorps ccnt2b, anticorps ccnt2a, anticorps ccnt2.S, anticorps ccnt2, anticorps Ccnt2

Sujet:

Description: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation, P-TEFB complex interacts with MYOD1, this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes, this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity).

Gene: CCNT2

Poids moléculaire: 81kDa

ID gène: 905

UniProt: O60583