PPP4R2 anticorps (Internal Region)

N° du produit ABIN6257426

Cet anticorps Lapin Polyclonal détecte spécifiquement PPP4R2 dans WB, ELISA, IF et ICC. Il présente une réactivité envers Humain.

Aperçu rapide pour PPP4R2 anticorps (Internal Region) (ABIN6257426)

Antigène: PPP4R2 (Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPP4R2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-PPP4R2 anticorps

Épitope: Internal Region

Specificité: PPP4R2 Antibody detects endogenous levels of total PPP4R2.

Homologie: Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human PPP4R2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur PPP4R2

Antigène: PPP4R2 (Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2))

Autre désignation: PPP4R2

Sujet:

Description: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.

Gene: PPP4R2

Poids moléculaire: 50 kDa

ID gène: 151987

UniProt: Q9NY27