RPS3 anticorps (Internal Region)

N° du produit ABIN6257472

Détail du produit anti-RPS3 anticorps

Antigène: RPS3 (Ribosomal Protein S3 (RPS3))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RPS3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: RPS3 Antibody detects endogenous levels of total RPS3.

Homologie: Pig,Zebrafish,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human RPS3, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur RPS3

Antigène: RPS3 (Ribosomal Protein S3 (RPS3))

Autre désignation: RPS3 (RPS3 Produits)

Synonymes: anticorps S3, anticorps D7Ertd795e, anticorps Rs_3, anticorps fb13d09, anticorps wu:fb13d09, anticorps zgc:56088, anticorps ribosomal protein S1a, anticorps rps3, anticorps 6779, anticorps CG6779, anticorps DmRpS3, anticorps Dmel\\CG6779, anticorps M(3)124, anticorps M(3)95A, anticorps M(3)B, anticorps M(3)B2, anticorps M(3)Fla, anticorps M(3)w, anticorps M(3R)w, anticorps M95A, anticorps M[[w]], anticorps Mw, anticorps RPS3, anticorps RS3, anticorps Rp S3, anticorps RpS, anticorps Rps3, anticorps X72921, anticorps dS3, anticorps rpS3, anticorps rpls1b, anticorps rpls3-b, anticorps ribosomal protein S3, anticorps 40S ribosomal protein S3, anticorps ribosomal protein S3 L homeolog, anticorps Ribosomal protein S3, anticorps 30S ribosomal protein S3, anticorps ribosomal protein S3 S homeolog, anticorps RPS3, anticorps Rps3, anticorps rps-3, anticorps rps3, anticorps rps3.L, anticorps RpS3, anticorps rps3.S

Sujet:

Description: Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).

Gene: RPS3

Poids moléculaire: 30 kDa

ID gène: 6188

UniProt: P23396

Pathways: Positive Regulation of Endopeptidase Activity