SF3B3 anticorps (C-Term)

N° du produit ABIN6257489

Détail du produit anti-SF3B3 anticorps

Antigène: SF3B3 (Splicing Factor 3b, Subunit 3, 130kDa (SF3B3))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SF3B3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: SF3B3 Antibody detects endogenous levels of total SF3B3.

Homologie: Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human SF3B3, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur SF3B3

Antigène: SF3B3 (Splicing Factor 3b, Subunit 3, 130kDa (SF3B3))

Autre désignation: SF3B3 (SF3B3 Produits)

Synonymes: anticorps GB11574, anticorps rse1, anticorps sap130, anticorps sf3b130, anticorps staf130, anticorps sf3b3, anticorps 1810061H24Rik, anticorps 5730409A01Rik, anticorps AA409318, anticorps D8Ertd633e, anticorps RSE1, anticorps SAP130, anticorps mKIAA0017, anticorps ik:tdsubc_2b2, anticorps wu:fb81f05, anticorps xx:tdsubc_2b2, anticorps zgc:55440, anticorps SF3b130, anticorps STAF130, anticorps splicing factor 3b subunit 3, anticorps splicing factor 3B subunit 3, anticorps splicing factor 3b, subunit 3, 130kDa, anticorps splicing factor 3b subunit 3 L homeolog, anticorps splicing factor 3b, subunit 3, anticorps SF3B3, anticorps LOC550935, anticorps sf3b3, anticorps Sf3b3, anticorps LOC100178056, anticorps sf3b3.L

Sujet:

Description: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:10490618, PubMed:10882114, PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).

Gene: SF3B3

Poids moléculaire: 136 kDa

ID gène: 23450

UniProt: Q15393