DOCK1 anticorps (C-Term)

N° du produit ABIN6257863

Cet anticorps anti-DOCK1 est un anticorps Lapin Polyclonal détectant DOCK1 dans ELISA, WB, IHC, IF et ICC. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour DOCK1 anticorps (C-Term) (ABIN6257863)

Antigène: DOCK1 (Dedicator of Cytokinesis 1 (DOCK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DOCK1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-DOCK1 anticorps

Épitope: C-Term

Specificité: DOCK1 Antibody detects endogenous levels of total DOCK1.

Homologie: Zebrafish,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human DOCK1, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur DOCK1

Antigène: DOCK1 (Dedicator of Cytokinesis 1 (DOCK1))

Autre désignation: DOCK1

Sujet:

Description: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152).

Gene: DOCK1

Poids moléculaire: 215 kDa

ID gène: 1793

UniProt: Q14185

Pathways: Signaling of Hepatocyte Growth Factor Receptor