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PLK3 anticorps (Internal Region)

PLK3 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, ICC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6258103
  • Antigène Voir toutes PLK3 Anticorps
    PLK3 (Polo-Like Kinase 3 (PLK3))
    Épitope
    • 8
    • 8
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 45
    • 23
    • 8
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 41
    • 2
    • 2
    Lapin
    Clonalité
    • 45
    Polyclonal
    Conjugué
    • 23
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PLK3 est non-conjugé
    Application
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificité
    PLK3 Antibody detects endogenous levels of total PLK3.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human PLK3, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product PLK3 Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    PLK3 (Polo-Like Kinase 3 (PLK3))
    Autre désignation
    PLK3 (PLK3 Produits)
    Synonymes
    anticorps cnk, anticorps wu:fi35f10, anticorps fnk, anticorps prk, anticorps plx3, anticorps MGC89507, anticorps PLK2/3, anticorps NV15469, anticorps Plx3, anticorps CNK, anticorps FNK, anticorps PRK, anticorps Cnk, anticorps Fnk, anticorps polo-like kinase 3 (Drosophila), anticorps polo like kinase 3, anticorps polo-like kinase 3, anticorps polo-like kinase 3 S homeolog, anticorps polo-like kinase 3 L homeolog, anticorps Serine/threonine-protein kinase plk-3, anticorps plk3, anticorps PLK3, anticorps LOC100118436, anticorps plk3.S, anticorps plk3.L, anticorps Plk3, anticorps plk-3
    Sujet

    Description: Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.

    Gene: PLK3

    Poids moléculaire
    70 kDa
    ID gène
    1263
    UniProt
    Q9H4B4
    Pathways
    Regulation of long-term Neuronal Synaptic Plasticity
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