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RORA anticorps (N-Term)

RORA Reactivité: Humain, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6258311
  • Antigène Voir toutes RORA Anticorps
    RORA (RAR-Related Orphan Receptor A (RORA))
    Épitope
    • 15
    • 9
    • 8
    • 7
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 86
    • 43
    • 41
    • 13
    • 11
    • 10
    • 10
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 1
    Humain, Rat
    Hôte
    • 81
    • 5
    Lapin
    Clonalité
    • 82
    • 4
    Polyclonal
    Conjugué
    • 46
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RORA est non-conjugé
    Application
    • 69
    • 27
    • 15
    • 11
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    RORA Antibody detects endogenous levels of total RORA.
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human RORA, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product RORA Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    RORA (RAR-Related Orphan Receptor A (RORA))
    Autre désignation
    RORA (RORA Produits)
    Synonymes
    anticorps ror1, anticorps ror2, anticorps ror3, anticorps rzra, anticorps nr1f1, anticorps MGC146531, anticorps NR1F1, anticorps ROR1, anticorps ROR2, anticorps ROR3, anticorps RZR-ALPHA, anticorps RZRA, anticorps RORalpha-B, anticorps gb:dq017624, anticorps rora2, anticorps 9530021D13Rik, anticorps Nr1f1, anticorps nmf267, anticorps sg, anticorps staggerer, anticorps tmgc26, anticorps RORalpha1, anticorps RAR related orphan receptor A, anticorps RAR-related orphan receptor A, anticorps RAR-related orphan receptor A, paralog a, anticorps RAR-related orphan receptor alpha, anticorps RORA, anticorps rora, anticorps Rora, anticorps roraa
    Sujet

    Description: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development, regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. Regulates the circadian expression of several clock genes, including CLOCK, ARNTL/BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC and PCK1. In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms. May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4+ T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellular stress. May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling.

    Gene: RORA

    Poids moléculaire
    60 kDa
    ID gène
    6095
    UniProt
    P35398
    Pathways
    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
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