Nesprin3 anticorps (N-Term)

N° du produit ABIN6258552

Détail du produit anti-Nesprin3 anticorps

Antigène: Nesprin3 (C14orf49) (Chromosome 14 Open Reading Frame 49 (C14orf49))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nesprin3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: C14orf49 Antibody detects endogenous levels of total C14orf49.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human C14orf49, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur Nesprin3

Antigène: Nesprin3 (C14orf49) (Chromosome 14 Open Reading Frame 49 (C14orf49))

Autre désignation: SYNE3 (C14orf49 Produits)

Synonymes: anticorps C14orf49, anticorps NET53, anticorps Nesp3, anticorps 4831426I19Rik, anticorps nesprin-3, anticorps spectrin repeat containing nuclear envelope family member 3, anticorps spectrin repeat containing, nuclear envelope family member 3, anticorps SYNE3, anticorps Syne3

Sujet:

Description: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.

Gene: SYNE3

Poids moléculaire: 130 kDa

ID gène: 161176

UniProt: Q6ZMZ3

Pathways: Maintenance of Protein Location