BHLHE41 anticorps (N-Term)

N° du produit ABIN6258612

L’anticorps Lapin Polyclonal anti-BHLHE41 a été validé pour WB, ELISA, IF et ICC. Il convient pour détecter BHLHE41 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour BHLHE41 anticorps (N-Term) (ABIN6258612)

Antigène: BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BHLHE41 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-BHLHE41 anticorps

Épitope: N-Term

Specificité: BHLHB3 Antibody detects endogenous levels of total BHLHB3.

Homologie: Pig,Bovine,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human BHLHB3, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur BHLHE41

Antigène: BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))

Autre désignation: BHLHE41

Sujet:

Description: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.

Gene: BHLHE41

Poids moléculaire: 50 kDa

ID gène: 79365

UniProt: Q9C0J9

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development