FIL1h anticorps (C-Term)

N° du produit ABIN6259273

Détail du produit anti-FIL1h anticorps

Antigène: FIL1h (Interleukin 1 eta (FIL1h))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FIL1h est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: IL1F8 Antibody detects endogenous levels of total IL1F8.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human IL1F8, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Date de péremption: 12 months

Détails sur FIL1h

Antigène: FIL1h (Interleukin 1 eta (FIL1h))

Autre désignation: IL36B (FIL1h Produits)

Synonymes: anticorps 2310043N20Rik, anticorps Il36b, anticorps FIL1, anticorps FIL1-(ETA), anticorps FIL1H, anticorps FILI-(ETA), anticorps IL-1F8, anticorps IL-1H2, anticorps IL1-ETA, anticorps IL1F8, anticorps IL1H2, anticorps Il1f8, anticorps interleukin 1 family, member 8, anticorps interleukin 36 beta, anticorps interleukin 36, beta, anticorps Il1f8, anticorps IL36B, anticorps Il36b

Sujet:

Description: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response, similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.

Gene: IL36B

Poids moléculaire: 17 kDa?

ID gène: 27177

UniProt: Q9NZH7