RRAGA/B anticorps

N° du produit ABIN6259340

Cet anticorps Lapin Polyclonal détecte spécifiquement RRAGA/B dans ELISA, WB, ICC et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour RRAGA/B anticorps (ABIN6259340)

Antigène: RRAGA/B (Ras-Related GTP Binding A/B (RRAGA/B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RRAGA/B est non-conjugé

Application: ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-RRAGA/B anticorps

Specificité: RRAGA/B Antibody detects endogenous levels of total RRAGA/B

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide

Isotype: IgG

Information d'application

Indications d'application: WB 1:500~1:1000, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur RRAGA/B

Antigène: RRAGA/B (Ras-Related GTP Binding A/B (RRAGA/B))

Autre désignation: RRAGA/B

Sujet:

Description: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.

Gene: RRAGA

Poids moléculaire: 34 kDa

ID gène: 10670

UniProt: Q7L523, Q5VZM2