TADA2L anticorps

N° du produit ABIN6259764

L’anticorps Lapin Polyclonal anti-TADA2L a été validé pour WB, ELISA, IF et ICC. Il convient pour détecter TADA2L dans des échantillons de Humain, Souris, Rat et Singe.

Aperçu rapide pour TADA2L anticorps (ABIN6259764)

Antigène: TADA2L (TADA2A) (Transcriptional Adaptor 2A (TADA2A))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TADA2L est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-TADA2L anticorps

Specificité: ADA2L antibody detects endogenous levels of total ADA2L

Réactivité croisée: Humain, Singe, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ADA2L

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500~1:3000, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur TADA2L

Antigène: TADA2L (TADA2A) (Transcriptional Adaptor 2A (TADA2A))

Autre désignation: ADA2L

Sujet:

Description: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376).

Gene: TADA2A

Poids moléculaire: 47kDa

ID gène: 6871

UniProt: O75478

Pathways: Chromatin Binding